Resource Type

Journal Article 986

Conference Videos 102

Conference Information 1

Year

2024 5

2023 123

2022 159

2021 204

2020 91

2019 58

2018 30

2017 28

2016 54

2015 38

2014 26

2013 29

2012 37

2011 22

2010 23

2009 36

2008 26

2007 38

2006 4

2005 4

open ︾

Keywords

1 15

activated carbon 14

2 7

Activated sludge 7

Deep learning 7

adsorption 7

Machine learning 6

Reinforcement learning 5

PD-L1 4

activated 4

drug resistance 4

hepatocellular carcinoma 4

kinetics 4

optimization 4

prognosis 4

1) 3

Multi-agent system 3

adsorption isotherm 3

21st-Century Maritime Silk Road 2

open ︾

Search scope:

排序： Display mode:

PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 399-403 doi: 10.1007/s11684-014-0380-9

Abstract: <p>We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinase1 (PAK1), a member of a serine/threonine protein kinase family.Despite the large body of evidence from studies in noncardiac tissue indicating that PAK1 activity iskey in the regulation of a number of cellular functions, the role of PAK1 in the heart has only beenWe discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its

Keywords： p21-activated kinase 1 (PAK1)     heart    

HTML PDF Collect

Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 248-252 doi: 10.1007/s11684-007-0047-x

Abstract: The aim of this study was to investigate the role of p38 mitogen-activated protein kinase (MAPK) in cellWestern blot was performed to detect the phosphorylation of p38 in NIH3T3 cells treated with PDGF.the migration of NIH3T3 cells and the influence of deficiency on this process in a gene knockout (p38MAP kinase was simultaneously phosphorylated.embryonic fibroblasts (MEFs) (〈0.001) as compared with the wild type cells (p38). p38 MAPK plays an important

Keywords： control     stimulation     mitogen-activated     growth factor     process    

HTML PDF Collect

Clinical characteristics and prognostic values of 1p32.3 deletion detected through fluorescence

Huanping Wang, Haitao Meng, Jinghan Wang, Yinjun Lou, Yile Zhou, Peipei Lin, Fenglin Li, Lin Liu, Huan Xu, Min Yang, Jie Jin

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 327-334 doi: 10.1007/s11684-019-0712-x

Abstract: This study aimed to investigate the prevalence, clinical characteristics, and prognostic impact of 1p32.3), gain(1q21), del(17p13), del(13q14), t(4;14), and t(11;14).Results showed that 8.3% of patients with MM were detected with del(1p32.3) and had significantly moreMultivariate analysis revealed that del(1p32.3) remained a powerful independent factor with worse PFSPatients with del(1p32.3) under bortezomib-based treatments tended to have short PFS and OS.

Keywords： 1p32.3 deletion     1q21 gain     prognosis     multiple myeloma     FISH     bortezomib     thalidomide    

HTML PDF Collect

Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 2,   Pages 123-138 doi: 10.1007/s11705-022-2194-7

Abstract: The two-electron cytoplasmic reductase NAD(P)H:quinone oxidoreductase 1 is expressed in many tissues.NAD(P)H:quinone oxidoreductase 1 is well-known for being highly expressed in most cancers.quinone oxidoreductase 1 to diagnose tumours.H:quinone oxidoreductase 1-activating drug β-lapachone.H:quinone oxidoreductase 1.

Keywords： NAD(P)H:quinone oxidoreductase 1     cancer therapy     target     probe     nanosystem    

HTML PDF Collect

Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 481-489 doi: 10.1007/s11684-016-0494-3

Abstract: <p>The tumor suppressor gene liver kinase B1 (LKB1), also called STK11, encodes a serine/threonine kinaseIn this study, LKB1 conditional knockout mice (LKB1Pax2 CKO mice) were generated usingLKB1Pax2 CKO mice died perinatally.LKB1 deficiency in LKB1Pax2 CKO mice thus disrupted hair cell planar polarity duringOur results suggest that LKB1 is required in PCP formation in cochlear hair cells in mice.p>

Keywords： LKB1     stereociliary bundles     kinocilium     planar cell polarity     hearing     mice    

HTML PDF Collect

noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

Frontiers of Medicine   Pages 924-938 doi: 10.1007/s11684-023-1004-z

Abstract: Mechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-relatedEVH1 domain-containing protein 1, which is necessary for suppressing tumor metastasis and inhibiting

Keywords： ovarian cancer     lncRNA LOC646029     metastasis     microRNA 627-3p     SPRED1    

HTML PDF Collect

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like

Fang, Joan Cao, Jitesh P.

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 462-476 doi: 10.1007/s11684-013-0270-6

Abstract: <p>Evaluating the effects of novel drugs on appropriate tumor models has become crucial for developingTreating these CSC-like cells with gemcitabine alone and a combination of gemcitabine and the novel CHK1p>

Keywords： drug resistance     cancer stem cell     checkpoint kinase 1 (CHK1)     PF-00477736     lung cancer     tumorigenicity    

HTML PDF Collect

Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 232-237 doi: 10.1007/s11705-012-1286-1

Abstract: Three groups of animals were examined respectively for inoculation of inhibitor of p38 MAPK (mitogenactivated protein kinase) SB 203580 and JNK inhibitor SP 600125, and a control.Light microscopy, immunohistochemistry, and tensometry revealed that the inhibition of p38 or JNK cascadesSB203580 inhibits the expression of p38, c-Jun and c-Fos.When we have used the JNK blocker, the expression of c-Fos and c-Jun decreased, but the expression of p38

Keywords： connective tissue     mitogen activated protein kinase (MAPK)     p38     JNK    

HTML PDF Collect

breast cancer cells from accumulating replication stress by ensuring productive splicing of checkpoint kinasecancer cells from accumulating replication stress by ensuring productive splicing of checkpoint kinase 1

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 186-195 doi: 10.1007/s11705-015-1540-4

Abstract: These exons include a critical exon within the checkpoint kinase 1 (CHK1) gene that plays a crucial functionBreast cancer cells depleted for Tra2 proteins have reduced CHK1 protein levels and accumulate DNA damage

Keywords： RNA splicing     gene expression     breast cancer     DNA damage     CHK1    

HTML PDF Collect

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 248-262 doi: 10.1007/s11684-012-0206-6

Abstract: <p>The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is presentBoth human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesisWe also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting theRecently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and mayp>

Keywords： AML1-ETO     mouse model     leukemia     t(8     21)     pathway hits     mutation     hematopoiesis     Kasumi-1     CD34+    

HTML PDF Collect

Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 309-315 doi: 10.1007/s11684-009-0043-4

Abstract: Proteinase-activated receptors (PARs) are a novel subclass of seven transmembrane-spanning, G protein-coupledHowever, little is known about the function of PAR-1, 2 in acute graft host disease (GVHD).In the present study, we first detected the expression of PAR-1, 2 protein and mRNA in a murine modelPAR-1, 2 protein expression was in accordance with the mRNA expression, as shown by Western blot.PAR-1 and PAR-2 may play an important role in the pathogenesis of acute GVHD.

Keywords： graft vs host disease     proteinase-activated receptor     murine model     hematopoietic stem cell transplantation    

HTML PDF Collect

Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 46-53 doi: 10.1007/s11684-010-0010-0

Abstract: Mitogen-activated protein kinase (MAPK) signaling pathway, one of the most important signaling pathwaysSo far, inhibitors specifically against each subfamilies of MAP kinase have been developed, while moreMost of the kinase inhibitors exert their functions in an ATP-competitive way or a non-ATP-competitiveinhibitors and their therapeutic roles in the treatment of diseases are helpful for the illumination of MAP kinase

Keywords： mitogen-activated protein kinase     drug target     inhibitor     signal transduction     disease    

HTML PDF Collect

Deciphering the Origins of P1-Induced Power Losses in Cu(Inx,Ga1–x Article

César Omar Ramírez Quiroz, Laura-Isabelle Dion-Bertrand, Christoph J. Brabec, Joachim Müller, Kay Orgassa

Engineering 2020, Volume 6, Issue 12,   Pages 1395-1402 doi: 10.1016/j.eng.2019.12.019

Abstract: Specifically, by analyzing the standard P1 patterning line ablated before the CIGS deposition, we revealWe further rationalize the origins of this effect by comparing the topography of the P1 edge throughWe also investigate the laser-induced damage on P1 patterning lines performed after the deposition ofOur findings pave the way for a better understanding of P1-induced power losses and introduce new insightsp>

Keywords： Cu(Inx     Ga1-x)Se2     Cell-to-module efficiency gap     P1-induced power losses     Hyperspectral photoluminescence    

HTML PDF Collect

Synthesis of zeolite Na-P1 from coal fly ash produced by gasification and its application as adsorbent

Yixin Zhang, Lu Zhou, Liqing Chen, Yang Guo, Fanhui Guo, Jianjun Wu, Baiqian Dai

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 3,   Pages 518-527 doi: 10.1007/s11705-020-1926-9

Abstract: The coal fly ash produced by gasification is estimated to be over 80 million ton per year in China by 2021. It has mainly been disposed as solid waste by landfill. There is lack of study focused on its utilization. In this paper, the coal fly ash produced by gasification was at first analyzed and then applied to synthesize zeolite as an adsorbent. The effects of synthesis conditions on the cation exchange capacity (CEC) of zeolite were investigated. The results from X-ray diffraction and scanning electron microscope indicated that the crystallinity of the synthesized zeolite is the most important factor to affect the CEC. When the synthesized zeolite with the highest CEC (275.5 meq/100 g) was used for the adsorption of Cr(VI) from aqueous solution, the maximum adsorption capacity for Cr(VI) was found to be 17.924 mg/g. The effects of pH, contact time and initial concentration on the adsorption of Cr(VI) were also investigated. The adsorption kinetics and isotherms can be well described by the pseudo-second-order model and Langmuir isotherm model, respectively.

Keywords： coal fly ash     gasification     zeolite     Na-P1     chromium(VI)    

HTML PDF Collect

Adsorption of 1,3-propanediol from synthetic mixture using polymeric resin as adsorbents

TANTAYAKOM, P. PRASITCHOKE, C. MUANGNAPOH

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 1,   Pages 52-57 doi: 10.1007/s11705-009-0087-7

Abstract: The aim of this work was to separate 1,3-PDO from a synthetic mixture using polymeric resins, AmberliteThe equilibrium adsorption of 1,3-PDO onto two polymeric resins were investigated in binary and tertiary-PDO at 160 g/L onto XAD-7 and XAD-16 was 835.96 and 584.61 mg 1,3-PDO/g dry resin, respectively.The value of n of 1,3-PDO adsorbed on XAD-7 are much higher than those on XAD-16.than XAD-16, the adsorption capacity of 1,3-PDO at 160 g/L onto XAD-16 was higher than XAD-7.

Keywords： adsorption     1     3-propanediol     glycerol     polymeric resin     adsorption isotherm    

HTML PDF Collect

Title Author Date Type Operation

PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Journal Article

Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

Journal Article

Clinical characteristics and prognostic values of 1p32.3 deletion detected through fluorescence

Huanping Wang, Haitao Meng, Jinghan Wang, Yinjun Lou, Yile Zhou, Peipei Lin, Fenglin Li, Lin Liu, Huan Xu, Min Yang, Jie Jin

Journal Article

Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Journal Article

Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Journal Article

noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

Journal Article

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like

Fang, Joan Cao, Jitesh P.

Journal Article

Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Journal Article

breast cancer cells from accumulating replication stress by ensuring productive splicing of checkpoint kinasecancer cells from accumulating replication stress by ensuring productive splicing of checkpoint kinase 1

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

Journal Article

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Journal Article

Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Journal Article

Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Journal Article

Deciphering the Origins of P1-Induced Power Losses in Cu(Inx,Ga1–x

César Omar Ramírez Quiroz, Laura-Isabelle Dion-Bertrand, Christoph J. Brabec, Joachim Müller, Kay Orgassa

Journal Article

Synthesis of zeolite Na-P1 from coal fly ash produced by gasification and its application as adsorbent

Yixin Zhang, Lu Zhou, Liqing Chen, Yang Guo, Fanhui Guo, Jianjun Wu, Baiqian Dai

Journal Article

Adsorption of 1,3-propanediol from synthetic mixture using polymeric resin as adsorbents

TANTAYAKOM, P. PRASITCHOKE, C. MUANGNAPOH

Journal Article